Bile from the hemojuvelin-deficient mouse model of iron excess is enriched in iron and ferritin.

ABSTRACT: Iron is an essential nutrient but is toxic in excess. Iron deficiency is the most prevalent nutritional deficiency and typically linked to inadequate intake. Iron excess is also common and usually due to genetic defects that perturb expression of hepcidin, a hormone that inhibits dietary iron absorption. Our understanding of iron absorption far exceeds that of iron excretion, which is believed to contribute minimally to iron homeostasis. Prior to the discovery of hepcidin, multiple studies showed that excess iron undergoes biliary excretion. We recently reported that wild-type mice raised on an iron-rich diet have increased bile levels of iron and ferritin, a multi-subunit iron storage protein. Given that genetic defects leading to excessive iron absorption are much more common causes of i

SUBMITTER: Prajapati M 

PROVIDER: S-EPMC11459263 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature