Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control.

ABSTRACT:

Background

Immune checkpoint blockade (ICB) therapies are an important treatment for patients with advanced cancers; however, only a subset of patients with certain types of cancer achieve durable remission. Cancer vaccines are an attractive strategy to boost patient immune responses, but less is known about whether and how immunization can induce long-term tumor immune reprogramming and arrest cancer progression. We developed a clinically relevant genetic cancer mouse model in which hepatocytes sporadically undergo oncogenic transformation. We compared how tumor-specific CD8 T cells (TST) differentiated in mice with early sporadic lesions as compared with late lesions and tested how immunotherapeutic strategies, including vaccination and ICB, impact TST function and liver cancer p

SUBMITTER: Detres Roman CR 

PROVIDER: S-EPMC11459355 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature