Directly Isolated Allogeneic Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy.

ABSTRACT:

Importance

Progressive multifocal leukoencephalopathy (PML) is a life-threatening viral infection with no approved antiviral treatment.

Objective

To determine whether restoring the compromised immune system of patients with PML with directly isolated allogeneic virus-specific (DIAVIS) T cells is a promising therapeutic strategy, especially if other curative options are absent.

Design, setting, and participants

A retrospective case series of patients with PML who were treated with DIAVIS T cells was conducted between March 2020 and February 2022. T cells were isolated from healthy donors within 24 hours and targeted against the BK polyomavirus. Patients with PML were treated monocentrically. Eligibility for treatment with DIAVIS T cells was assessed for patients with c

SUBMITTER: Mohn N 

PROVIDER: S-EPMC11459361 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature