Group sequential testing of a treatment effect using a surrogate marker.

ABSTRACT: The identification of surrogate markers is motivated by their potential to make decisions sooner about a treatment effect. However, few methods have been developed to actually use a surrogate marker to test for a treatment effect in a future study. Most existing methods consider combining surrogate marker and primary outcome information to test for a treatment effect, rely on fully parametric methods where strict parametric assumptions are made about the relationship between the surrogate and the outcome, and/or assume the surrogate marker is measured at only a single time point. Recent work has proposed a nonparametric test for a treatment effect using only surrogate marker information measured at a single time point by borrowing information learned from a prior study where both the surro

SUBMITTER: Parast L 

PROVIDER: S-EPMC11459368 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature