Indeterminate etiology of acute liver failure in North America: Less common, still grave prognosis.

ABSTRACT:

Background

The etiology of acute liver failure (ALF) remains one of the most important factors in determining prognosis and predicting outcomes. In a significant proportion of ALF cases, however, the etiology remains unknown and is categorized as indeterminate ALF (IND-ALF). In this study, we summarize findings from patients with IND-ALF from 32 transplant centers across the United States, and we compare laboratory, prognostic, and outcome data for patients with IND-ALF.

Methods

Between 1998 and 2019, 3364 adult patients with ALF or acute liver injury (ALI) from 32 liver transplant centers were enrolled in the ALFSG registry. The primary clinical outcome of interest was 21-day transplant-free survival (TFS).

Results

Of the 3364 patients enrolled in the ALFSG registry,

SUBMITTER: Patel PV 

PROVIDER: S-EPMC11459373 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature