Genome-Wide Meta-Analysis of Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Parkinson's Disease Cohorts.

ABSTRACT:

Background

Amyloid-β, phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal fluid are established biomarkers for Alzheimer's disease (AD). In other neurodegenerative diseases, such as Parkinson's disease (PD), these biomarkers have also been found to be altered, and the molecular mechanisms responsible for these alterations are still under investigation. Moreover, the interplay between these mechanisms and the diverse underlying disease states remains to be elucidated.

Objective

To investigate genetic contributions to the AD biomarkers and assess the commonality and heterogeneity of the associations per underlying disease status.

Methods

We conducted genome-wide association studies (GWASs) for the AD biomarkers on subjects from the Parkinson's Progression

SUBMITTER: Ta M 

PROVIDER: S-EPMC11459375 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature