Coronary artery calcification is prevalent in systemic sclerosis and is associated with adverse prognosis.

ABSTRACT:

Objective

Coronary artery calcification assessed on thoracic computed tomography represents the calcific component of established coronary artery disease, is a biomarker of total atheromatous plaque burden and predicts mortality. Systemic sclerosis is a pro-inflammatory condition, and inflammation is also a driver of coronary artery disease. We assessed coronary artery calcification prevalence, mortality risk and potential clinical impact on primary prevention in a cohort of patients with systemic sclerosis, differentiated by clinical phenotype including the presence of interstitial lung disease and pulmonary arterial hypertension.

Methods

Retrospective analysis of 258 computed tomographies in systemic sclerosis patients from three prospectively maintained clinical and resea

SUBMITTER: Rossdale J 

PROVIDER: S-EPMC11459481 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature