EphA-Mediated Regulation of Stomatin Expression in Prostate Cancer Cells.

ABSTRACT:

Background and aims

Tumor growth and progression are affected by interactions between tumor cells and stromal cells within the tumor microenvironment. We previously showed that the expression of an integral membrane protein, called stomatin, was increased in cancer cells following their association with stromal cells. Additionally, stomatin impaired the Akt signaling pathway to suppress tumor growth. However, it remains unclear how stomatin expression is regulated. To explore this, we examined the cell surface molecules that can transduce the intercellular communication signals between cancer cells and stromal cells.

Results

Among these molecules, EphA3 and EphA7 receptors and their ligand ephrin-A5 were found to be expressed in prostate cancer cells, but not in prostate str

SUBMITTER: Nishida M 

PROVIDER: S-EPMC11459579 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature