Stressful life events across the lifespan and inflammation: An integrative data analysis.

ABSTRACT: Experiencing more stressful life events has been linked to higher levels of inflammation, but this association may depend on when in the lifespan the stressors occur. To address this knowledge gap, we tested two lifespan theories, the accumulation of risks and sensitive period models, by assessing the association between the total number of stressful events and their life stage occurrence on later-life C-reactive protein (CRP). We harmonized data across two cohort studies, maximizing variation in stressors reported across the lifespan. Participants (N_total = 7,952, 57.7% female, M_age = 69) from the Health and Retirement Study (HRS: n = 5,136, M_age = 70.6) and the English Longitudinal Study of Aging (ELSA: n = 2,816, M_age = 66.1) completed retrosp

SUBMITTER: Hillmann AR 

PROVIDER: S-EPMC11459650 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature