Hypoxemia events in preterm neonates are associated with urine oxidative biomarkers.

ABSTRACT:

Background

Intermittent hypoxemia (IH) events are common in preterm neonates and are associated with adverse outcomes. Animal IH models can induce oxidative stress. We hypothesized that an association exists between IH and elevated peroxidation products in preterm neonates.

Methods

Time in hypoxemia, frequency of IH, and duration of IH events were assessed from a prospective cohort of 170 neonates (<31 weeks gestation). Urine was collected at 1 week and 1 month. Samples were analyzed for lipid, protein, and DNA oxidation biomarkers.

Results

At 1 week, adjusted multiple quantile regression showed positive associations between several hypoxemia parameters with various individual quantiles of isofurans, neurofurans, dihomo-isoprostanes, dihomo-isofurans, and ortho-tyrosi

SUBMITTER: Raffay TM 

PROVIDER: S-EPMC11459675 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature