The cumulative impact of clinical risk on brain networks and associations with executive function impairments in adolescents with congenital heart disease.

ABSTRACT: Patients with congenital heart disease (CHD) demonstrate altered structural brain network connectivity. However, there is large variability between reported results and little information is available to identify those patients at highest risk for brain alterations. Thus, we aimed to investigate if network connectivity measures were associated with the individual patient's cumulative load of clinical risk factors and with family-environmental factors in a cohort of adolescents with CHD. Further, we investigated associations with executive function impairments. In 53 adolescents with CHD who underwent open-heart surgery during infancy, and 75 healthy controls, diffusion magnetic resonance imaging and neuropsychological assessment was conducted at a mean age of 13.2 ± 1.3 years. Structural c

SUBMITTER: Ehrler M 

PROVIDER: S-EPMC11459682 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature