Identifying prothrombin and bone sialoprotein as potential drug targets for idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease with scarce therapeutic alternatives, which imposes a significant economic burden on society. The identification of novel drug targets is thus critically essential. Plasma proteins with discernible causal evidence hold promise as viable drug targets for this condition.

Methods

We performed a proteome-wide Mendelian randomization (MR) analysis to assess the causal effects of 4,907 circulating proteins from the deCODE study on the risk of IPF from the Finngen Database (2,018 cases vs. 373,064 controls). We further replicated the MR analysis in 1426 proteins from the ARIC study and IPF from the UK Biobank (1,369 cases vs. 435,866 controls). Then a series of analyses including Bayesian colocalization, Steiger filt

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11459707 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature