Comprehensive identification, isolation, and culture of human breast cell types.

ABSTRACT: Tissues are formed and shaped by cells of many different types and are orchestrated through countless interactions. Deciphering a tissue's biological complexity thus requires studying it at cell-level resolution, where molecular and biochemical features of different cell types can be explored and thoroughly dissected. Unfortunately, the lack of comprehensive methods to identify, isolate, and culture each cell type from many tissues has impeded progress. Here, we present a method for the breadth of cell types composing the human breast. Our goal has long been to understand the essence of each of these different breast cell types, to reveal the underlying biology explaining their intrinsic features, the consequences of interactions, and their contributions to the tissue. This biological expl

SUBMITTER: Thi K 

PROVIDER: S-EPMC11459906 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature