High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in <i>Helicobacter pylori</i>.

ABSTRACT: The burgeoning emergence of drug-resistant Helicobacter pylori strains poses a significant challenge to the clinical success of eradication therapies and is primarily attributed to mutations within drug-targeting genes that lead to antibiotic resistance. This study investigated the effect of high salt conditions on the occurrence of drug-resistance mutations in H. pylori. We found that high salt condition significantly amplifies the frequency of drug resistance mutations in H. pylori. This can be chiefly attributed to our discovery indicating that high salt concentration results in elevated reactive oxygen species (ROS) levels, initiating DNA damage within H. pylori. Mechanistically, high salt condition suppresses lipopolysaccharide (LPS) synthesis gene expressi

SUBMITTER: Huang H 

PROVIDER: S-EPMC11459920 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature