Evolution toward extremely high imipenem resistance in <i>Mycobacterium abscessus</i> outbreak strains.

ABSTRACT: Treatment of Mycobacterium abscessus pulmonary disease requires multiple antibiotics including intravenous β-lactams (e.g., imipenem). M. abscessus produces a β-lactamase (Bla_Mab) that inactivates β-lactam drugs but less efficiently carbapenems. Due to intrinsic and acquired resistance in M. abscessus and poor clinical outcomes, it is critical to understand the development of antibiotic resistance both within the host and in the setting of outbreaks. We compared serial longitudinally collected M. abscessus subsp. massiliense isolates from the index case of a cystic fibrosis center outbreak and four outbreak-related strains. We found strikingly high imipenem resistance in the later patient isolates, including the outbreak strain (MIC > 512 µg/mL

SUBMITTER: Le Run E 

PROVIDER: S-EPMC11459939 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature