Zidovudine in synergistic combination with nitrofurantoin or omadacycline: <i>in vitro</i> and in murine urinary tract or lung infection evaluation against multidrug-resistant <i>Klebsiella pneumoniae</i>.

ABSTRACT: Limited treatment options and multidrug-resistant (MDR) Klebsiella pneumoniae present a significant therapeutic challenge, underscoring the need for novel approaches. Drug repurposing is a promising tool for augmenting the activity of many antibiotics. This study aimed to identify novel synergistic drug combinations against K. pneumoniae based on drug repurposing. We used the clinically isolated GN 172867 MDR strain of K. pneumoniae to determine the reversal resistance activity of zidovudine (AZT). The combined effects of AZT and various antibiotics, including nitrofurantoin (NIT) and omadacycline (OMC), were examined using the checkerboard method, growth curves, and crystal violet assays to assess biofilms. An in vitro combination activity testing was carried o

SUBMITTER: Tian P 

PROVIDER: S-EPMC11459972 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature