Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure.

ABSTRACT:

Background

Acute liver failure (ALF) is a critical condition characterized by rapid liver dysfunction, leading to high mortality rates. Current treatments are limited, primarily supportive, and often require liver transplantation. This study investigates the potential of a novel nanoparticle formulation of glutathione (GSH) and virgin coconut oil (VCO) alone and in combination to enhance therapeutic outcomes in a rat model of ALF induced by orogastric carbon tetrachloride (CCl₄).

Methods

The study employed adult male Albino rats divided into ten groups, with ALF induced via a single oral dose of CCl₄. Various treatment regimens were administered over seven days, including conventional and nanoparticle forms of GSH and VCO and their combinations. The eff

SUBMITTER: Allam EAH 

PROVIDER: S-EPMC11460069 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature