Effects of simulated smoke condensate generated from combustion of selected military burn pit contents on human airway epithelial cells.

ABSTRACT:

Background

Exposure to military burn pit smoke during deployment is associated with different respiratory and non-respiratory diseases. However, information linking smoke exposure to human pulmonary health is lacking. This study examined the effects of simulated burn pit smoke condensates on human airway epithelial cells (HAECs) from twelve donors (smokers/non-smokers, biological female/male) cultured at an air-liquid interface and exposed to condensates from three simulated burn pit waste materials (cardboard, plywood, and plastic) incinerated at two combustion conditions: smoldering and flaming. Cellular gene expression was analyzed using bulk RNA sequencing, and basolateral media cytokine levels were assessed using multiplex immunoassay.

Results

Flaming smoke condensates

SUBMITTER: Ghosh A 

PROVIDER: S-EPMC11460082 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature