Exploring the complex immunomodulatory effects and gut defense via oral administration of Astragali radix water extract to normal mice.

ABSTRACT:

Background

Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines. It exhibits diverse biological activities, including immunomodulatory and anti-inflammatory properties; however, some of its activities have only been demonstrated in vitro.

Objective

To examine the effects of orally administered AR extract on immune cells and the intestine under physiological conditions, which bridges the gap between previously observed in vitro outcomes and in vivo results.

Methods

AR extract was prepared by hot water extraction. Three separate animal experiments were conducted to isolate macrophages, splenocytes, and the small intestine epithelium. For the macrophage preparation experiment, an intraperitoneal injection of sterile thioglycolate was a

SUBMITTER: Lee MG 

PROVIDER: S-EPMC11460088 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature