The impact of the physicochemical properties of calcium phosphate ceramics on biocompatibility and osteogenic differentiation of mesenchymal stem cells.

ABSTRACT:

Objective

In this study we have focused on biocompatibility and osteoinductive capacity analysis of self-manufactured single-phase (HAP) and two-phase (HAP and β-ТСР) bioactive ceramics with various chemical modifications (Fig. 1).

Results

We demonstrate a reduction in solubility for all analyzed composite after the treatment with H₂O and H₂O₂, accompanied by an enhancement in adsorption activity. This modification also resulted in an increase in micro- and macroporosity, along with a rise in the open porosity. Adipose-derived mesenchymal stromal cells demonstrated excellent cell adhesion and survival when cultured with these ceramics. Calcium phosphate ceramics (H-500, HT-500, and HT-1 series) stimulated alkaline phosphatase expression, prom

SUBMITTER: Skliarenko Y 

PROVIDER: S-EPMC11460134 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature