Breast Cancer Incidence and Exposure to Metalworking Fluid in a Cohort of Female Autoworkers.

ABSTRACT: Breast cancer is the leading cancer diagnosed among women, and environmental studies have produced few leads on modifiable risk factors for breast cancer. Following an Institute of Medicine recommendation for occupational studies of women highly exposed to potential breast cancer risk factors, we took advantage of an existing cohort of 4,503 female autoworkers in Michigan exposed to metalworking fluid (MWF), complex mixtures of oils and chemicals widely used in metal manufacturing worldwide. Cox proportional hazards models were fit to estimate hazard ratios for incident breast cancer (follow-up, 1985-2013) and cumulative exposure (20-year lag) to straight mineral oils (a known human carcinogen) and water-based soluble and synthetic MWF. Because the state cancer registry began decades after

SUBMITTER: Garcia E 

PROVIDER: S-EPMC11460202 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature