Cyclodextrin metal-organic framework@SiO₂ nanocomposites for poorly soluble drug loading and release.

ABSTRACT: The development of non-toxic drug carrier materials with high loading capacity, sustained release properties, stability, and biocompatibility holds significant medical value and potential for loading and releasing poorly soluble drugs. In this study, we synthesized a biocompatible, non-toxic, environmentally friendly CD-MOF porous material with high specific surface area and tunable structure. By incorporating SiO₂ to enhance the stability of MOF materials, the synthesized CD-MOF@SiO₂ material shows promising applications in drug delivery. The obtained CD-MOF@SiO₂ nanocomposite was utilized as a carrier for the poorly soluble drug, folic acid. Characterization of the drug-loaded composite before and after drug loading was performed using scanning electron m

SUBMITTER: Liu S 

PROVIDER: S-EPMC11460221 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature