IL-7Rα on CD4⁺ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis.

ABSTRACT:

Background

The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4⁺ T cells and their differentiation to effector/memory CD4⁺ T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. However, it has been reported that IL-7Rα on peripheral CD4⁺ T cells is disposable for their maintenance and EAE pathogenesis, which does not align with the body of knowledge on the role of IL-7Rα in the biology of CD4⁺ T cells. Given that a definitive study on this important topic is lacking, we revisited it using a novel approach, an inducible knockout of the IL-

SUBMITTER: Azizi G 

PROVIDER: S-EPMC11460225 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature