Performance of simplified methods for quantification of [¹⁸F]NaF uptake in fibrodysplasia ossificans progressiva.

ABSTRACT:

Background

Fibrodysplasia Ossificans Progressiva (FOP) is a rare, genetic disease in which heterotopic bone is formed in muscles, tendons and ligaments throughout the body. Disease progression is variable over time and between individuals. ¹⁸F-fluoride uptake in newly formed bone can be evaluated using [¹⁸F]NaF (i.e., sodiumfluoride) PET/CT, identifying active areas of bone formation in FOP. The purpose of this study was to assess the performance of various semi-quantitative methods with full kinetic analysis.

Results

Seven patients (age range: 20-31 years) with FOP underwent dynamic [¹⁸F]NaF scans at baseline and after one year. [¹⁸F]NaF uptake was measured in aorta descendens, vertebrae, heterotopic bone lesions and metabolically

SUBMITTER: de Ruiter RD 

PROVIDER: S-EPMC11460293 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature