Kidney Function Modifies the Effect of Intraoperative Opioid Dosage on Postoperative Delirium.

ABSTRACT:

Background

There are few studies demonstrating how kidney function affects the risk of developing delirium in older adult surgical patients administered opioids. This study determined whether baseline kidney function influences the relationship between morphine equivalent dose and the development of delirium on postoperative day (POD) 2 in patients with hip fracture.

Methods

This retrospective study analyzed emergency department (ED) estimated glomerular filtration rate (eGFR), perioperative serum creatinine, intravenous morphine equivalents, and POD2 delirium assessment by the Confusion Assessment Method in 652 patients aged 65 years or older without preoperative delirium. ED eGFR was used to divide subjects into groups by presence or absence of chronic kidney disease (CKD)

SUBMITTER: Davani AB 

PROVIDER: S-EPMC11460320 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature