Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency.

ABSTRACT: Protein S deficiency (PSD) is an autosomal dominant disorder characterized by congenital thrombophilia. Studies on PSD are limited yet, resulting in a lack of clarity about molecular changes during abnormal coagulation. Proteomics and metabolomics analyses were conducted on the plasma of PSD patients based on liquid and gas chromatography-mass spectrometry (LC- and GC-MS). Differential proteins and metabolites of PSD were then filtered by univariate statistical analysis and subjected to network analysis using the ingenuity pathway analysis (IPA) platform. The proteome and metabolome of PSD were obviously disturbed, and the biological pathway of coagulation and complement cascades was the most affected. During PSD, overall levels of anticoagulant protein decreased and negative regulation of

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11460325 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature