Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis.

ABSTRACT:

Background & aims

Biochemical response to ursodeoxycholic acid (UDCA) therapy is associated with good prognosis in people living with primary biliary cholangitis (PBC). Biochemical response is typically assessed early in disease and it is not known what proportion of patients lose previously attained biochemical response, nor whether this impacts long-term liver transplant (LT)-free survival.

Methods

We identified all UDCA-treated patients with PBC from the Canadian Network for Autoimmune Liver disease with biochemical measurements at 1 year, and evaluated their liver biochemistry over time. Inadequate biochemical response was defined as serum alkaline phosphatase ≥1.67x the upper limit of normal or abnormal serum total bilirubin at 1 year of UDCA therapy and all time points

SUBMITTER: Roberts SB 

PROVIDER: S-EPMC11460452 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature