Inflammation in liver fibrosis and atrial fibrillation: A prospective population-based proteomic study.

ABSTRACT:

Background & aims

Elevated liver stiffness has been associated with atrial fibrillation (AFib) in the general population. The mechanism underlying this association is unclear.

Methods

Participants were recruited from the general population and prospectively enrolled with follow-up for 5 years. The fibrosis-4 (FIB-4) index was used as a surrogate marker for liver fibrosis. Proteomics analysis was performed using the 92-target Olink inflammation panel. Validation was performed using the NAFLD fibrosis score (NFS), aspartate aminotransferase to platelet index (APRI), and repeat confirmation proteomics.

Results

A sample of 11,509 participants with a mean age of 54.0 ± 11.1 years, 51.3% women, and a median FIB-4 index of 0.85 (0.65/1.12), was used. The FIB-4 index was pred

SUBMITTER: Boeckmans J 

PROVIDER: S-EPMC11460462 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature