Personalized PDAC chip with functional endothelial barrier for tumour biomarker detection: A platform for precision medicine applications.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterised by poor survival rates and an increasing global incidence. Advances in the staging and categorization of pancreatic tumours, along with the discovery of functional mutations, have made precision treatments possible, which may lead to better clinical results. To further improve customized treatment approaches, in vitro models that can be used for functional drug sensitivity testing and precisely mimic the disease at the organ level are required. In this study, we present a workflow for creating a personalized PDAC chip utilising primary tumour-derived human pancreatic organoids (hPOs) and Human Umbilical Vein Endothelial Cells (HUVECs) to simulate the vascular barrier and tumour interactions within a PDMS-fr

SUBMITTER: Goluba K 

PROVIDER: S-EPMC11460472 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature