Aged gut microbiota promotes arrhythmia susceptibility via oxidative stress.

ABSTRACT: Arrhythmias and sudden cardiac death (SCD) impose a significant burden. Their prevalence rises with age and is linked to gut dysbiosis. Our study aimed to determine whether aged gut microbiota affects arrhythmogenesis. Here, we demonstrated that arrhythmia susceptibility in aged mice could be transmitted to young mice using fecal microbiota transplantation (FMT). Mechanistically, increased intestinal reactive oxygen species (ROS) in aged mice reduced ion channel protein expression and promoted arrhythmias. Gut microbiota depletion by an antibiotic cocktail reduced ROS and arrhythmia in aged mice. Interestingly, oxidative stress in heart induced by hydrogen peroxide (H₂O₂) increased arrhythmia. Moreover, aged gut microbiota could induce oxidative stress in young mice c

SUBMITTER: Fu ZP 

PROVIDER: S-EPMC11460473 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature