Obesity-driven changes in breast tissue exhibit a pro-angiogenic extracellular matrix signature.

ABSTRACT: Obesity has reached epidemic proportions in the United States, emerging as a risk factor for the onset of breast cancer and a harbinger of unfavorable outcomes [1], [2], [3]. Despite limited understanding of the precise mechanisms, both obesity and breast cancer are associated with extracellular matrix (ECM) rewiring [4], [5], [6]. Utilizing total breast tissue proteomics, we analyzed normal-weight (18.5 to < 25 kg/m²), overweight (25 to < 30 kg/m²), and obese (≥30 kg/m²) individuals to identify potential ECM modifying proteins for cancer development and acceleration. Obese individuals exhibited substantial ECM alterations, marked by increased basement membrane deposition, angiogenic signatures, and ECM-modifying proteins. Notably, the collagen IV crosslink

SUBMITTER: Bamberg EE 

PROVIDER: S-EPMC11460480 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature