Retinal Pigment Epithelium Curvature Can Predict Late Age-Related Macular Degeneration.

ABSTRACT:

Purpose

Outer retinal band integrity strongly predicts late age-related macular degeneration (AMD). However, it is often assessed subjectively as "continuity" using inconsistent definitions. Alternatively, "curvature" of the outer retinal bands is a quantitative metric that strongly correlates with AMD biomarkers and can screen for intermediate AMD. We evaluated the prognostic ability of retinal pigment epithelium (RPE) and ellipsoid zone (EZ) curvature for late AMD against outer retinal band continuity, pigmentary abnormalities, reticular pseudodrusen, and drusen volume.

Methods

Consecutive patients with intermediate AMD who progressed to late AMD (n = 17) or remained stable (n = 42) were recruited. RPE and EZ curvature were quantified as a ratio of their lengths over Bruch

SUBMITTER: Cheung R 

PROVIDER: S-EPMC11460567 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature