A Bidirectional Mendelian Randomization Study of the Causal Association Between Ischemic Stroke, Coronary Heart Disease, and Hydrocephalus.

ABSTRACT:

Background

The association among coronary heart disease, ischemic stroke, and hydrocephalus remains ambiguous.

Objectives

There is a need for a Mendelian randomization study to evaluate the underlying causality between coronary heart disease, ischemic stroke, and hydrocephalus.

Methods

The data source utilized genome-wide association studies, employing a threshold of p < 5 × 10^-8 to identify single nucleotide polymorphisms strongly linked to ischemic stroke and coronary heart disease as instrumental variables (IVs). Five methods-inverse variance weighted (IVW), Mendelian randomization (MR) Egger, Weighted Median, Weighted mode, and Simple mode-utilized the selected IVs to estimate the causality between ischemic stroke, coronary heart disease, and hydrocepha

SUBMITTER: Wang W 

PROVIDER: S-EPMC11460635 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature