<i>In vivo</i> volumetric analysis of retinal vascular hemodynamics in mice with spatio-temporal optical coherence tomography.

ABSTRACT:

Significance

Microcirculation and neurovascular coupling are important parameters to study in neurological and neuro-ophthalmic conditions. As the retina shares many similarities with the cerebral cortex and is optically accessible, a special focus is directed to assessing the chorioretinal structure, microvasculature, and hemodynamics of mice, a vital animal model for vision and neuroscience research.

Aim

We aim to introduce an optical imaging tool enabling in vivo volumetric mouse retinal monitoring of vascular hemodynamics with high temporal resolution.

Approach

We translated the spatio-temporal optical coherence tomography (STOC-T) technique into the field of small animal imaging by designing a new optical system that could compensate for the mouse eye refr

SUBMITTER: Wegrzyn P 

PROVIDER: S-EPMC11460669 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature