Efficacy of a Single Administration of 5% Povidone-Iodine in the Treatment of Adenoviral Conjunctivitis.

ABSTRACT:

Purpose

To evaluate the safety and efficacy of a single, in-office administration of 5% povidone-iodine (PVP-I) compared to artificial tears (AT) for adenoviral conjunctivitis (Ad-Cs).

Design

Double-masked pilot randomized trial.

Methods

Patients presenting with presumed adenoviral conjunctivitis were screened at 9 U.S. clinics.

Inclusion criteria

≥18 years of age, symptoms ≤4 days, and a positive AdenoPlus test.

Exclusion criteria

thyroid disease, iodine allergy, recent ocular surgery, and ocular findings inconsistent with early-stage Ad-Cs. Randomization was to a single administration of 5% PVP-I or AT in 1 eye and examinations on days 1-2, 4, 7, 14, and 21 with conjunctival swabs taken at each visit for quantitative polymerase chain reaction. Primary

SUBMITTER: Than T 

PROVIDER: S-EPMC11460794 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature