Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank.

ABSTRACT:

Background

Previous studies have shown that major surgical and medical hospital admissions are associated with cognitive decline in older people (aged 40-69 years at recruitment), which is concerning for patients and caregivers. We aimed to validate these findings in a large cohort and investigate associations with neurodegeneration using MRI.

Methods

For this population-based study, we analysed data from the UK Biobank collected from March 13, 2006, to July 16, 2023, linked to the National Health Service Hospital Episode Statistics database, excluding participants with dementia diagnoses. We constructed fully adjusted models that included age, time, sex, Lancet Commission dementia risk factors, stroke, and hospital admissions with a participant random effect. Primary outcom

SUBMITTER: Taylor J 

PROVIDER: S-EPMC11460833 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature