Construction and validation of an immune-related gene signature predictive of survival and response to immunotherapy for colorectal cancer.

ABSTRACT: Colorectal cancer is a common malignant tumor with the second incidence rate and the third mortality rate worldwide. In this study, we identified and validated an immune-related gene signature, explored the clinical and molecular characteristics of the signature-defined risk groups, and assessed its ability in predicting prognosis, immune cell infiltration and immunotherapy responses. The Cancer Genome Atlas database was used as the training set while GSE39582 database as the validation set. Immune-related hub genes were selected by the Least Absolute Shrinkage and Selection Operator-penalized Cox regression model, and the signature was then constructed by the selected genes and their relevant coefficients. Prognostic performance of the signature and the signature-base nomogram models were

SUBMITTER: Li C 

PROVIDER: S-EPMC11460896 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature