Ex Vivo Modeling of Atrioventricular Valve Mechanics in Single Ventricle Physiology.

ABSTRACT: Single ventricle physiology (SVP) is used to describe any congenital heart lesion that is unable to support independent pulmonary and systemic circulations. Current treatment strategies rely on a series of palliation surgeries that culminate in the Fontan physiology, which relies on the single functioning ventricle to provide systemic circulation while passively routing venous return through the pulmonary circulation. Despite significant reductions in early mortality, the presence of atrioventricular valve (AVV) regurgitation is a key predictor of heart failure in these patients. We sought to evaluate the biomechanical changes associated with the AVV in SVP physiologies. Left and right ventricles were sutured onto patient-derived 3D-printed mounts and mounted into an ex vivo systemic heart

SUBMITTER: Moye SC 

PROVIDER: S-EPMC11460979 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature