Validation of the AJCC 8th Edition Breast Cancer Prognostic Staging System in Legacy Alliance Trials (AFT-01).

ABSTRACT:

Background

The 8th edition American Joint Committee on Cancer staging system combined anatomic stage (AS) with receptor status and grade to create prognostic stage (PS). PS has been validated in single-institution and cancer registry studies; however, missing human epidermal growth factor receptor 2 (HER2) status and variable treatment and follow-up create limitations.

Objective

Our objective was to compare the relative prognostic ability of PS versus AS to predict survival using breast cancer clinical trial data.

Methods

Women with non-metastatic breast cancer enrolled in six Alliance for Clinical Trials in Oncology trials were included (enrollment years 1997-2010). AS and PS were constructed using pathological tumor size, nodal status, estrogen receptor (ER), proges

SUBMITTER: Krecko LK 

PROVIDER: S-EPMC11460990 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature