New experiments and models to describe soluble surfactant adsorption above and below the critical micelle concentration.

ABSTRACT:

Hypothesis

Lysopalmitoylphosphatidylcholine (LysoPC) is a soluble single-chain surfactant product of the innate immune system degradation of double-chain phospholipids. LysoPC adsorption to the air-water interface in lung alveoli can be modeled using alveolar-sized bubbles of constant surface area in a capillary pressure microtensiometer to show that adsorption is diffusion limited both below and above the critical micelle concentration (CMC). Above the CMC, a local equilibrium model is proposed in which depletion of the local monomer concentration drives dissociation of micelles in a region near the bubble surface.

Experimental

A capillary pressure microtensiometer in which a feedback loop maintains a constant bubble radius and surface area is used to measure dynamic surfac

SUBMITTER: Huang B 

PROVIDER: S-EPMC11461105 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature