Difference between kidney function by cystatin C versus creatinine and association with muscle mass and frailty.

ABSTRACT:

Background

A higher difference in estimated glomerular filtration rate by cystatin C versus creatinine (eGFRDiff = eGFRCys - eGFRCreat) is associated with decreased frailty risk. Since eGFRCreat is influenced by muscle more than eGFRCys, muscle mass may explain this association. Previous work could not account for this when considering regional muscle measures by imaging. Deuterated creatine (D₃Cr) dilution measures whole body muscle mass (kilograms). We aimed to determine whether eGFRDiff is associated with D₃Cr muscle mass and whether muscle mass explains the association between eGFRDiff and frailty.

Methods

Cross-sectional analysis within the multicenter MrOS Study at Year 14 (visit 4). 490 men of the original cohort of 5994 MrOS participants (aged ≥

SUBMITTER: Yuan JH 

PROVIDER: S-EPMC11461133 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature