RET overexpression leads to increased brain metastatic competency in luminal breast cancer.

ABSTRACT:

Background

Breast cancer brain metastasis is a rising occurrence, necessitating a better understanding of the mechanisms involved for effective management. Breast cancer brain metastases diverge notably from the primary tumor, with gains in kinase and concomitant losses of steroid signaling observed. In this study, we explored the role of the kinase receptor RET in promoting breast cancer brain metastases and provide a rationale for targeting this receptor.

Methods

RET expression was characterized in a cohort of patients with primary and brain metastatic tumors. RET functionality was assessed using pharmacological inhibition and gene silencing in patient-derived brain metastatic tumor explants and in vivo models, organoid models, and brain organotypic cultures. RNA sequencin

SUBMITTER: Jagust P 

PROVIDER: S-EPMC11461165 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature