Long non-coding RNA FAM87A is associated with overall survival and promotes cell migration and invasion in gastric cancer.

ABSTRACT:

Background

The role of long non-coding RNAs (lncRNAs) in the invasion and metastasis of gastric cancer remains largely unclear.

Methods

Integrating transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, differentially expressed genes were identified in gastric cancer. Using the Catalogue of Somatic Mutations in Cancer (COSMIC) database-curated gene set, lncRNAs associated with invasion and metastasis were identified. The Cox analyses were performed to identify prognostic lncRNAs. The competing endogenous RNA (ceRNA) regulation network was constructed to identify hub lncRNAs in gastric cancer. Functional and pathway analyses were used to investigate the function of identified lncRNAs. RT-qPCR and Transwell assays were used to inves

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11461168 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature