Metabolite, immunocyte phenotype, and lymphoma: a Mendelian randomization study.

ABSTRACT:

Background

Recent studies have confirmed that metabolites and immunocyte phenotype may be associated with the risk of lymphoma. However, the bidirectional causality between metabolites, immunocyte phenotype, disease risk, and whether immunity is an intermediate mediator between metabolism and lymphoma causality is still unclear.

Objective

To elucidate the causal relationship between metabolites, immune cell phenotypes, and lymphomas, we used two-sample Mendelian randomization (MR) and two-step MR analysis.

Methods

Applying large-scale genome-wide association studies (GWAS) pooled data, we selected 1400 metabolites and 731 immunocyte phenotypes with eight lymphoma subtypes for two-sample bi-directional MR analysis. In addition, we used two-step MR to quantify the propo

SUBMITTER: Fan C 

PROVIDER: S-EPMC11461196 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature