Selected stem cell populations in pediatric acute lymphoblastic leukemia.

ABSTRACT:

Introduction

Acute lymphoblastic leukemia is characterized by a disturbed maturation of hematopoietic stem cells (HSCs) resulting in development of a malignant clone. Despite relatively positive outcome, there are still instances of disease relapse occurring due to ineffective disease eradication or primary leukemic clone alterations. Unclear significance of stem cells in the course of ALL led us to investigate and establish crucial changes in two stem cell populations - very small embryonic-like stem cells (VSELs) and HSCs during the induction phase of treatment.

Methods

In a retrospective study selected stem cells in peripheral blood and bone marrow of 60 pediatric ALL subjects and 48 healthy controls were subjected to flow cytometric analysis at 4 different time points.

SUBMITTER: Kretowska-Grunwald A 

PROVIDER: S-EPMC11461207 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature