Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation.

ABSTRACT:

Introduction

Modern histocompatibility algorithms depend on the comparison and analysis of high-resolution HLA protein sequences and structures, especially when considering epitope-based algorithms, which aim to model the interactions involved in antibody or T cell binding. HLA genotype imputation can be performed in the cases where only low/intermediate-resolution HLA genotype is available or if specific loci are missing, and by providing an individuals' race/ethnicity/ancestry information, imputation results can be more accurate. This study assesses the effect of imputing high-resolution genotypes on molecular mismatch scores under a variety of ancestry assumptions.

Methods

We compared molecular matching scores from "ground-truth" high-resolution genotypes against scores f

SUBMITTER: Matern BM 

PROVIDER: S-EPMC11461215 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature