Dysregulated mTOR networks in experimental sporadic Alzheimer's disease.

ABSTRACT:

Background

Beyond the signature amyloid-beta plaques and neurofibrillary tangles, Alzheimer's disease (AD) has been shown to exhibit dysregulated metabolic signaling through insulin and insulin-like growth factor (IGF) networks that crosstalk with the mechanistic target of rapamycin (mTOR). Its broad impact on brain structure and function suggests that mTOR is likely an important therapeutic target for AD.

Objective

This study characterizes temporal lobe (TL) mTOR signaling abnormalities in a rat model of sporadic AD neurodegeneration.

Methods

Long Evans rats were given intracerebroventricular injections of streptozotocin (ic-STZ) or saline (control), and 4 weeks later, they were administered neurobehavioral tests followed by terminal harvesting of the TLs for histopa

SUBMITTER: de la Monte SM 

PROVIDER: S-EPMC11461251 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature