Causal effects of lipid-lowering drugs on skin diseases: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Although previous studies have indicated an association between low-density lipoprotein (LDL) and skin diseases, their causal effects remain inconclusive. This study aimed to assess the causal relationship between genetically proxied lipid-lowering drugs and skin cancers and psoriasis.

Methods

Two-sample Mendelian randomization (MR) analysis was performed using single-nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was used to determine causal relationships. The "leave-one-out" sensitivity test, Cochran's Q-statistic and MR-Egger intercept were used to assess heterogeneity and horizontal pleiotropy.

Results

We identified 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and propro

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11461303 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature