Quantitative brain T1 maps derived from T1-weighted MRI acquisitions: a proof-of-concept study.

ABSTRACT:

Background

Longitudinal T1 relaxation time is a key imaging biomarker. In addition, T1 values are modulated by the administration of T1 contrast agents used in patients with tumors and metastases. However, in clinical practice, dedicated T1 mapping sequences are often not included in brain MRI protocols. The aim of this study is to address the absence of dedicated T1 mapping sequences in imaging protocol by deriving T1 maps from standard T1-weighted sequences.

Methods

A phantom, composed of 144 solutions of paramagnetic agents at different concentrations, was imaged with a three-dimensional (3D) T1-weighed turbo spin-echo (TSE) sequence designed for brain imaging. The relationship between the T1 values and the signal intensities was established using this phantom acquisition

SUBMITTER: Lavielle A 

PROVIDER: S-EPMC11461398 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature