An in vitro evaluation of intravenous lipid emulsion on three common canine toxicants.

ABSTRACT:

Objective

To determine whether intravenous lipid emulsion (ILE) therapy significantly reduces the concentration of baclofen, ibuprofen, and/or bromethalin in canine whole blood over time.

Animals

Seven 500 mL bags of canine DEA 1.1 negative blood were divided into aliquots of 125 mL and randomly assigned to one of three treatment groups (baclofen, ibuprofen, bromethalin) or four control groups (a positive control for each treatment group and a negative control group).

Procedures

Injectable ibuprofen (200 mg/kg), baclofen (8 mg/kg), or bromethalin (3 mg/kg) was apportioned into 125 mL aliquots of canine whole blood and incubated for 30 min at 38.5°C. ILE (12.4 mL, Intralipid^® ) was added to each sample and the solution vortexed [215 rpm for 15 min at

SUBMITTER: Jones E 

PROVIDER: S-EPMC11461450 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature